La labor del Protomedicato en la salud pública en el virreinato del Perú / O trabalho do Protomedicato na saúde pública no vice-reinado do Peru / The work of the Protomedicato in public health in the viceroyalty of Peru

El objetivo de la presente investigación es conocer el papelque cumplió el Protomedicato en la salud publica en elvirreinato del Perú. La metodología utilizada fue la narraciónhistórica siguiendo el método heurístico y hermenéutico,utilizando fuentes primarias documentales de archivoshistóricos peruanos y españoles. El resultado obtenido fueconfirmar que el Protomedicato veló por la salud de losvecinos y que tenía carácter administrativo judicial y susfunciones principales fueron regularizar la labor de los queejercieran cualquier tipo de atención sanitaria, otorgandolicencias, fijando aranceles y vigilando el trabajo realizadoen las boticas y la calidad de los medicamentos, a través devisitas periódicas. La conclusión determina que hubo mejorassanitarias como consecuencia de la gestión del Protomedicatoen el virreinato del Perú, proponiendo medidas salubrese, incluso, disponía la movilización de personal médico através del virreinato y participaba ante cualquier consultade otras entidades coloniales, como el cabildo, referentes asalud pública, como eliminación de acequias, declaraciónde pestes, y otros.(AU)

The objective of this research is to know the role that theProtomedicato played in public health in the viceroyaltyof Peru. The methodology used was historical narrationfollowing the heuristic and hermeneutic method, usingprimary documentary sources from Peruvian and Spanishhistorical archives. The result obtained was to confirm thatthe Protomedicato looked after the health of the neighborsand that it had a judicial administrative nature and its main functions were to regularize the work of those whocarried out any type of health care, granting licenses, settingtariffs and monitoring the work carried out in pharmaciesand the quality of medicines, through periodic visits. Theconclusion determines that there were health improvementsas a consequence of the management of the Protomedicato inthe viceroyalty of Peru, proposing health measures and evenordered the mobilization of medical personnel throughoutthe viceroyalty and participated in any consultation fromother colonial entities, such as the council, referring to publichealth, such as elimination of ditches, declaration of pests,and others.(AU)

O objetivo desta pesquisa é conhecer o papel que o Protomedicatodesempenhou na saúde pública no vice-reinado do Peru. Ametodologia utilizada foi a narração histórica seguindo o métodoheurístico e hermenêutico, utilizando fontes documentaisprimárias de arquivos históricos peruanos e espanhóis. Oresultado obtido foi confirmar que o Protomedicato zelava pelasaúde dos vizinhos e que tinha caráter administrativo judiciale suas principais funções eram regularizar o trabalho de quemrealizava qualquer tipo de assistência à saúde, concedendolicenças, fixando tarifas e acompanhamento do trabalhorealizado nas farmácias e da qualidade dos medicamentos,através de visitas periódicas. A conclusão determina quehouve melhorias na saúde como consequência da gestão doProtomedicato no vice-reinado do Peru, propondo medidassanitárias e ainda ordenou a mobilização de pessoal médicoem todo o vice-reinado e participou de qualquer consultade outras entidades coloniais, como o conselho. , referentesà saúde pública, como eliminação de valas, declaração depragas, entre outros.(AU)

Francisco Sánchez, filósofo y médico gallego, precursor de la Medicina Basada en la Evidencia / Francisco Sánchez, Galician philosopher and medical doctor, precursor of Evidence Based Medicine

November 16 marked the 400th anniversary of the death, in Toulouse, of Francisco Sánchez de Sousa, known as "the Skeptic" or "the Tudense" who was, without a doubt, the most prestigious doctor and philosopher in the history of Galicia. With a versatile, multifaceted and cosmopolitan spirit, he represents the living incarnation of the Renaissance prototype of universal man. From a medical point of view, it could be said that our protagonist was a precursor of Evidence-Based Medicine, since he advocated a direct examination of things and submitting the data from the experience to analysis and critical judgment. The medical work of Francisco Sánchez is collected in a very heterogeneous conglomerate, published posthumously under the generic title of Opera Medica. It consists of a compilation of philosophical texts and a collection of various medical writings that includes notes, monographs, conferences, speeches and even notes for teaching. (AU)

El 16 de noviembre se cumplieron 400 años de la muerte, en Toulouse, de Francisco Sánchez de Sousa, conocido por “el Escéptico” o “el Tudense” que fue, sin duda alguna, el médico y filósofo más prestigioso de la historia de Galicia. De espíritu versátil, polifacético y cosmopolita, representa la encarnación viva del prototipo renacentista de hombre universal. Desde el punto de vista médico se podría decir que nuestro protagonista fue un precursor de la Medicina Basada en la Evidencia ya que propugnaba un examen directo de las cosas y someter los datos de la experiencia al análisis y al juicio crítico. La obra médica de Francisco Sánchez está recogida en un conglomerado muy heterogéneo, publicado de forma póstuma con el título genérico de Opera Medica. Consiste en una recopilación de textos filosóficos y una colección de diversos escritos médicos que incluye apuntes, monografías, conferencias, discursos e incluso notas para impartir la docencia. (AU)

Genetic continuity and change among the Indigenous peoples of California.

Before the colonial period, California harboured more language variation than all of Europe, and linguistic and archaeological analyses have led to many hypotheses to explain this diversity1. We report genome-wide data from 79 ancient individuals from California and 40 ancient individuals from Northern Mexico dating to 7,400-200 years before present (BP). Our analyses document long-term genetic continuity between people living on the Northern Channel Islands of California and the adjacent Santa Barbara mainland coast from 7,400 years BP to modern Chumash groups represented by individuals who lived around 200 years BP. The distinctive genetic lineages that characterize present-day and ancient people from Northwest Mexico increased in frequency in Southern and Central California by 5,200 years BP, providing evidence for northward migrations that are candidates for spreading Uto-Aztecan languages before the dispersal of maize agriculture from Mexico2-4. Individuals from Baja California share more alleles with the earliest individual from Central California in the dataset than with later individuals from Central California, potentially reflecting an earlier linguistic substrate, whose impact on local ancestry was diluted by later migrations from inland regions1,5. After 1,600 years BP, ancient individuals from the Channel Islands lived in communities with effective sizes similar to those in pre-agricultural Caribbean and Patagonia, and smaller than those on the California mainland and in sampled regions of Mexico.

Paracelso y la medicina del Renacimiento en el cine / Paracelsus and the Medicine of the Renaissance in the Cinema

La breve, azarosa y fructífera vida de Paracelso, médico del siglo XVI, motivó en 1943, aproximadamente 400 años después de su muerte, a un film homenaje alemán que rescató un fragmento de su existencia. El rodaje y estreno se realizó en plena segunda guerra mundial y fue controlado rigurosamente por el nazismo. Esto produjo determinadas polémicas, aún vigentes, relacionadas con su director. Este trabajo intenta dar cuenta de ambos hechos. (AU)

The brief, eventful and fruitful life of Paracelsus, a 16th century doctor, motivated a German tribute film in 1943, approximately 400 years after his death that rescued a fragment of his existence. The filming and premiere took place during the Second World War and was rigorously controlled by the Nazis. This produced certain controversies, still in force, related to its director. This paper intends to portrait both facts. (AU)

Alimentos sin finalidad nutricional en la terapéutica médica hospitalaria de la edad moderna en el Hospital de Santiago de Vitoria (Álava, España) / Food without nutritional purpose in the medical therapeutics in the modern age at Hospital de Santiago in Vitoria (Alava, Spain)

Introducción: con ser importante, la alimentación en los hospitales medievales y modernos distó de la excelencia y abundancia que sugierenalgunos historiadores, probablemente por una incorrecta valoración de la documentación hospitalaria al considerar como destinado a la alimentación todo gasto en alimentos, cuando buena parte tuvo como destino la botica.Objetivo/método: identificar los alimentos utilizados para una finalidad terapéutica no nutricional durante la edad moderna en el Hospital deSantiago Apóstol de Vitoria (Álava, España), describir su sistema de consignación y revisar la bibliografía del periodo para facilitar estrategias devaloración documental a los investigadores.Resultados: entre 1592 y 1813 se identifican 42 grupos de alimentos adquiridos para finalidades terapéuticas no nutritivas. El sistema deanotación en los libros de gastos no es sistemático ni homogéneo sino muy variable y dependiente de quien efectuara el asiento. Se identifican27 términos para el reconocimiento de que un determinado alimento tuviera por destino la botica y no la cocina. Se escogen 14 textos sanitariosdel periodo como bibliografía clarificadora, encontrándose de mayor utilidad para los fines propuestos los manuales enfermeros del siglo XVII.Conclusiones: la variedad y cantidad de alimentos destinados a la botica evidencia el riesgo de confusión en los investigadores no familiarizadosal analizar las dietas hospitalarias desde los libros de contabilidad. La propuesta de términos y estrategias de discriminación del uso nutricionalo no nutricional de los alimentos adquiridos, junto a la recomendación bibliográfica, resulta indispensable para una adecuada valoración de lasdietas hospitalarias históricas. (AU)

Introduction: although important, food in medieval and modern hospitals was far from the excellence and abundance suggested by somehistorians, probably due to an incorrect assessment of hospital documentation, considering all food expenditure to be for food when much of itwas destined for the apothecary’s shop.Aim/method: to identify the foodstuffs used for non-nutritional therapeutic purposes during the modern age at Hospital de Santiago in Vitoria(Alava, Spain), to describe the system of consignment, and to review the bibliography of the period in order to facilitate documentary assessmentstrategies for researchers.Results: between 1592 and 1813, 42 groups of foodstuffs acquired for non-nutritional therapeutic purposes were identified. The system of annotation in the expenditure books is neither systematic nor homogeneous, but highly variable and dependent on who made the entry. Twenty-seventerms were identified for the recognition that a given foodstuff was intended for the apothecary’s shop and not the kitchen. Fourteen sanitarytexts of the period were chosen as clarifying bibliography, finding the 17th century nursing manuals most useful for the proposed purposes.Conclusions: the variety and quantity of foodstuffs destined for the apothecary’s shop shows the risk of confusion in unfamiliar researcherswhen analysing hospital diets from account books. A proposal of terms and strategies for discriminating the nutritional or non-nutritional use ofthe food acquired, together with bibliographical recommendations, is essential for an adequate assessment of historical hospital diets. (AU)

[Brief introduction on compilation and editions of Yang ke xuan cui].

Yang ke xuan cui («¼) is a surgical work compiled by Chen Wenzhi () of the Ming Dynasty. There are few of research on the completion and author of the book. Based on the evidences in the local chronicles, the prefaces and postscripts of the book, it has been verified that the book was originally completed no later than 1591, and Chen Wenzhi passed away no later than 1623. After investigating the 6 editions collected by 8 institutions, a collection of 11 books in total, by comparing the characteristics and circulation relationship of each edition, two systems of circulation were sorted out: block-printed edition of Xu Xi () and review edition of Xu Dachun ().

La Academia de los Linceos y su historial de resurgimientos / The Lincei Academy and its History of Revivals

El manuscrito hace una revisión sobre la historia de la Academia de Los Linceanos creada a principios de siglo XVII con todas las vicisitudes que rodearon una existencia la cual ya supera los 500 años. Como una muestra cabal de sus claroscuros se efectúa un repaso de las peripecias atravesadas en los años del fascismo, la política antisemita que la atravesó y la posterior reconstitución concluida la guerra. Vayan pues para ella, los deseos de una travesía en plena armonía y no más sobresaltos. (AU)

The manuscript reviews the history of the Academy of the Linceans created at the beginning of the 17th century with all its ups and downs surrounding an existence that already exceeds 500 years. As a clear example of such chiaroscuro, an account of the threats experienced during the fascist period together with its piercing anti-Semitic policy, and the subsequent reconstitution after the war, is also made. Long live then to the Academy, and our very best wishes for a consonant future devoid of upsetting facts. (AU)

The Mysterious Life of Jeronimus Ruscelli and His Contribution to Nephrology (1504-1566).

Jeronimo Ruscelli was a mysterious humanist of great fame. He was born in Viterbo between 1504 and 1518 and died in Venice in 1566. Very little is known about Ruscelli's life, but based on his extensive literary output we can assume that he was endowed with remarkable intellectual abilities and a propensity for varied interests. At a young age, he developed a strong interest in classical studies and attended the court of Cardinal Marini Grimani in Utini. After completing his studies at the University of Padua, he participated in the founding of a humanist academy, the Accademia degli Sdegnati (the Scornful Academy). After his fruitful experience in Rome, he moved to the Neapolitan residence of Marquis Alfonso D'Avalos. Here, Ruscelli founded an "Academy of Secrets", composed of a group of humanists and nobles who had an extensive culture and had different experiences but similar interests. During these productive years, under the pseudonym Alexius Pedemontanus, he wrote one of his masterpieces, The Secreti, an important historical documentary manual of great value. In this book, the author proposes therapies for a wide variety of diseases, claiming in most cases that they have been experimentally and successfully tested in the presence of witnesses in at least 3 clinical cases. Ruscelli composed an extensive version of The Secreti, the Secreti Novi. In this book he reported more than a thousand recipes, the substances used were of a great variety and sometimes curious. According to Ruscelli, the recipes in this updated version of the book were "easy for anyone to make, of little effort, and useful for all kinds of people." The topics of this masterpiece range from general medical suggestions to more specific indications, with a wide variety of recipes and treatments of nephrological and urological interest.

On Kidney and Bladder Diseases in Nuzhat al-adhhan fi islah al-abdan by Physician Dawud b. 'Umar al-Antaki.

OBJECTIVES: Dawud b. 'Umar al-Antaki, known as the Avicenna of his time, was an Ottoman physician and scholar who wrote medical texts in Arabic in the 16th century. He was taught by an Iranian medical scholar, Muhammad Sharif, in the fields of logic, physical sciences, Greek, and medicine. After leaving Antioch, he traveled to Lebanon and then to Damascus, where he began writing his work, Tadhkiratu uli l-albab wa l-jami' li l-'ajab al-'ujab. Dawud b. 'Umar al-Antaki settled in Egypt, where he taught at the Zahiriyya Madrasa and practiced medicine before dying in Mecca in 1599. Here, we examined al-Antaki's writings on kidney and bladder diseases in his work Nuzhat al-adhhan fi islah al-abdan. MATERIALS AND METHODS: We translated sections on kidney and bladder diseases into English and compared Ilter Uzel's copy of Nuzhat al-adhhan fi islah al-abdan with a printed copy. We compared the relevant sections of Nuzhat al-adhhan fi islah al-abdan with the relevant sections of other important works of al-Antaki, al-Nuzhat al-mubhija fi tashhidh al-adhhan wa ta'dil al-amzija, and Tadhkiratu uli l-albab wa l-jami' li l-'ajab al-'ujab. The similarities and differences between these works were revealed. RESULTS: Kidney and bladder diseases are briefly discussed in Nuzhat al-adhhan fi islah al-abdan under the headings "amrad al-kula wa l-mathana," "al-hisa," and "harqan al-bawl wa taqtiruhu." CONCLUSIONS: Issues concerning kidney and bladder diseases are addressed more briefly in Nuzhat al-adhhan fi islah al-abdan than in al-Nuzhat al-mubhija fi tashhidh al-adhhan wa ta'dil al-amzija. Tadhkiratu uli l-albab wa l-jami' li l-'ajab al-'ujab consists solely of kidney and bladder stones. When these works are combined, the information in them complements each other.

The Emergence and Effects of the First Anatomy Theatres in Western Europe / El Surgimiento y los Efectos de las Primeras Salas de Anatomía en Europa Occidental

SUMMARY: The spread of the idea that the human body should be learned from cadavers, especially under the leadership of Vesalius, and the strong support of this idea among surgeons and medical students of that period, led to the emergence of anatomy theatres, particularly in the rich centres of Western Europe. Anatomy theatres have become prestigious places that make contributions to financial income for the cities they are located in. They have contributed to the importance of universities with the students they attract. Anatomy has become a more visual and international science because of the spread of anatomical drawings in scientific medical books, the newly invented printing press making it easier to print more books and the increasing interest of the people of the period. Learning medicine has become easier with the spread of visual anatomy books and cadaver studies. Cadaver studies and anatomy theatres, which started to become widespread under the leadership of brave science warriors such as Vesalius, who lived in the Renaissance period, became the subject of the paintings of painters of the period such as Rembrandt under the name anatomy activities. It is beneficial and necessary for society to keep in memory what this period brought to the world of anatomy and the present with its historical processes.

La difusión de la idea de que el cuerpo humano se debe aprender a partir de cadáveres, especialmente bajo el liderazgo de Vesalius, y el fuerte apoyo de esta idea entre los cirujanos y estudiantes de medicina de ese período, condujo al surgimiento de las salas de anatomía, particularmente en los ricos centros de Europa Occidental. Las salas de anatomía se han convertido en lugares de prestigio que contribuyen a los ingresos económicos de las ciudades en las que están ubicados y han contribuido a la importancia de las universidades con los estudiantes que atraen. La anatomía se ha convertido en una ciencia más visual e internacional debido a la difusión de los dibujos anatómicos en los libros médicos científicos, la imprenta recién inventada que facilita la impresión de libros y el creciente interés de la gente de la época. Aprender medicina se ha vuelto más fácil con la difusión de libros de anatomía visual y estudios de cadáveres. Los estudios de cadáveres y las salas de anatomía, que comenzaron a generalizarse bajo el liderazgo de valientes guerreros de la ciencia como Vesalius, que vivió en el Renacimiento, se convirtieron en el tema de las pinturas de artistas de la época como Rembrandt bajo el nombre de actividades de anatomía. Es beneficioso y necesario que la sociedad guarde en la memoria lo que este período trajo al mundo de la anatomía y el presente con sus procesos históricos.

Artificial intelligence's interpretation of the neuroanatomical aspect of Peter Paul Rubens's copy of "The Battle of Anghiari" by Leonardo da Vinci.

We tested to see how Ruben's copy of "The Battle of Anghiari" by Leonardo da Vinci would be interpreted by AI in a neuroanatomical aspect. We used WOMBO Dream, an artificial intelligence (AI)-based algorithm that creates images based on words and figures. The keyword we provided for the algorithm was "brain" and the reference image was Ruben's drawing. AI interpreted the whole drawing as a representation of the brain. The image generated by the algorithm was similar to our interpretation of the same painting.

Entwined African and Asian genetic roots of medieval peoples of the Swahili coast.

The urban peoples of the Swahili coast traded across eastern Africa and the Indian Ocean and were among the first practitioners of Islam among sub-Saharan people1,2. The extent to which these early interactions between Africans and non-Africans were accompanied by genetic exchange remains unknown. Here we report ancient DNA data for 80 individuals from 6 medieval and early modern (AD 1250-1800) coastal towns and an inland town after AD 1650. More than half of the DNA of many of the individuals from coastal towns originates from primarily female ancestors from Africa, with a large proportion-and occasionally more than half-of the DNA coming from Asian ancestors. The Asian ancestry includes components associated with Persia and India, with 80-90% of the Asian DNA originating from Persian men. Peoples of African and Asian origins began to mix by about AD 1000, coinciding with the large-scale adoption of Islam. Before about AD 1500, the Southwest Asian ancestry was mainly Persian-related, consistent with the narrative of the Kilwa Chronicle, the oldest history told by people of the Swahili coast3. After this time, the sources of DNA became increasingly Arabian, consistent with evidence of growing interactions with southern Arabia4. Subsequent interactions with Asian and African people further changed the ancestry of present-day people of the Swahili coast in relation to the medieval individuals whose DNA we sequenced.

An otolaryngological tour of Vesalius' De Humani Corporis Fabrica.

BACKGROUND: Andreas Vesalius published his famous anatomy book, De Humani Corporis Fabrica Libri Septum (On the Fabric of the Body in Seven Books), in 1543, with a second edition in 1555. This article explores the importance of this text to contemporary ENT, by demonstrating Vesalius' fresh, precise and hands-on approach to anatomy, and examines how this developed our understanding of ENT. METHODS: A second edition of De Humani Corporis Fabrica, held in John Rylands Library, University of Manchester, was examined in its digitised form and supplemented by secondary texts. RESULTS AND DISCUSSION: Where Vesalius' predecessors were rigid in their interpretation of anatomy, confined to the instruction of the Ancients, Vesalius showed that these teachings could be analysed and built on with careful observation. This is evident in his illustrations of, and annotations on, the skull base, ossicles and thyroid gland.

Gaspare Aselli (1581-1625) and Lacteis Venis: Four Centuries From the Discovery of Lymphatic System.

The first half of the seventeenth century may be seen as the turning point of knowledge of human anatomy and physiology, as also demonstrated by the works by William Harvey (1578-1657) on the circulation of the blood. This article aims to present biographic context of the surgeon Gaspare Aselli (1581-1625) and his rather fortuitous discovery of the lacteals in Milan in 1622, that contributed to the comprehension of the lymphatic system. The experimentation on living animals (anatomia animata, living anatomy), and particularly the vivisection used by Gaspare Aselli provided the basis for much of the subsequent investigation of the human physiology. In particular, the discovery of lymphatics challenged the basis of the Galenic doctrine, denying the liver the central role it had formerly been granted in transforming food into blood and revolutionized the ancient hepatocentrism in favor of the modern concept of cardiocentrism.

Exposed and Abandoned. Origins of the Foundling Hospital.

Abandoning undesired newborn infants was a Roman form of family limitation. They were exposed or given to foster mothers. Christianization alleviated their lot when in 374 CE, Emperor Valentinian's law provided some protection. The Milan Foundling Hospital was established in 787 CE. When the Carolingian Empire fell apart during the 10th century, monastic networks (the Holy Spirit Order and Daughters of Charity) took over social support for the poor, the sick, and the insane. Foundling hospitals proliferated in Italy between the 13th and 15th centuries, in France during the 16th and 17th, and in Germany and Austria in the 18th century. Metropolitan hospices admitted thousands of infants each year. Most were not "found" exposed but were admitted anonymously via a revolving box or registered in an open office. Soon after admission, they were transported for foster care to wet nurses in villages. Sick infants, especially those suspected of suffering from syphilis, were denied the breast, and artificial feeding was tried with little success. Official death statistics were falsified by relating infant deaths not to admissions but to the total number of children cared for. Over 60% died during their first year of life, mostly from pre-admission problems such as malformation, hypothermia, and disease; from poor hygiene in overcrowded wards; and from artificial feeding. Although not intended for that purpose, the hospices became medical research institutions when in late 18th century, physicians and surgeons were employed by maternity and foundling hospitals.